Integrating metabolic, transcriptional regulatory and signal transduction models in Escherichia coli

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Integrating metabolic, transcriptional regulatory and signal transduction models in Escherichia coli

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Full genome sequences enable the construction of genome-scale in silico models of complex cellular functions. Genome-scale constraints-based models of Escherichia coli metabolism have been constructed and used to successfully interpret and predict cellular behavior under a range of conditions. These previous models do not account for regulation of gene transcription and thus cannot accurately p...

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Topological units of environmental signal processing in the transcriptional regulatory network of Escherichia coli.

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2008

ISSN: 1460-2059,1367-4803

DOI: 10.1093/bioinformatics/btn352